Epifluorohydrin Property

Boiling point:

85-86 °C (lit.)

Density 

1.067 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.368(lit.)

Flash point:

40 °F

storage temp. 

0-6°C

form 

liquid

color 

clear

CAS DataBase Reference

503-09-3(CAS DataBase Reference)

NIST Chemistry Reference

Oxirane, (fluoromethyl)-(503-09-3)

EPA Substance Registry System

Epifluorohydrin (503-09-3)

Safety

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-34

Safety Statements 

16-26-45-38-36/37/39-33

RIDADR 

UN 2924 3/PG 2

WGK Germany 

3

RTECS 

TZ3325000

Hazard Note 

Flammable/Highly Toxic

HazardClass 

6.1(a)

PackingGroup 

I

HS Code 

2910900090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Epifluorohydrin Chemical Properties,Usage,Production

Chemical Properties

clear colourless liquid

Uses

Epifluorohydrin is used as a reagent in the synthesis of N-arylphosphoramidates. In addition, it is used in the synthesis of orally bioavailable ALK inhibitors in the treatment of tumors.

General Description

Clear colorless liquid.

Air & Water Reactions

Highly flammable. Water soluble.

Reactivity Profile

A halogenated epoxide. Epoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts. The chlorinated derivative has been shown to be incompatible with aniline, strong oxidizers, sulfuric acid, isopropylamine, zinc, aluminum, iron, etc. see epichlorohydrin.

Health Hazard

ACUTE/CHRONIC HAZARDS: Epifluorohydrin is a lacrimator. When heated to decomposition it emits toxic fumes.

Fire Hazard

Epifluorohydrin is flammable.